“Moderate coffee consumption may be associated with a reduction in the risk of certain diseases,” food scientist says.
Reprinted from: Coffeescience.org 2007
The symposium, Nutrigenomics: The New Science of Genes, Nutrition, and Health, was held here to introduce science writers to nutrigenomics, the new study of how foods affect our genes and how individual genetic differences affect the way we respond to nutrients in foods.
Dr. Coughlin told the group that habitual consumption of five or more cups of coffee a day has been associated with improved glucose regulation and a marked lower risk of acquiring type 2 diabetes. That means that there is a 35% to 75% lower risk of developing the disease as shown in studies in the
Liver disease is also affected positively by drinking coffee. The toxicologist said, “Coffee consumption has been associated with a clinically significant reduced risk of liver cancer and cirrhosis.” He said there are data that suggest the reduced risk of alcohol cirrhosis could be associated with the phenolics and related substances in coffee.
The scientist told the science writers that coffee might play a role in cancer protection, also due to its naturally occurring polyphenolic antioxidants as well as heat-produced antioxidants. He said that there are studies from a number of countries that have shown that coffee is the major single source of dietary antioxidants – far more than tea, wine, chocolate, and individual fruits and vegetables. Furthermore, some coffee components can induce the expression of carcinogen-detoxifying enzymes, he noted.
Coffee seems to reduce the risk of Parkinson’s disease, according to epidemiological studies. Dr. Coughlin said, “Some research in neuropharmacology suggests that only one cup of coffee a day – that amounts to 80 to 140 mg of caffeine – can halve the risk of getting Parkinson’s disease. This might be because caffeine’s adenosine-blocking power may be one mechanism through which the brain cells in Parkinson’s disease are protected or conserved.”
Dr. Coughlin told the attendees, “Numerous other studies have shown that drinking coffee increases your mental alertness, cognitive functions, physical stamina and wakefulness. It has also been shown to reduce the risk of
“There is a long established history of the safe use of coffee, and the newest detailed studies and re-examinations of old issues have been quite reassuring,” Dr. Coughlin noted. “Coffee and caffeine should already be recognized for their positive health benefits and potential functional food attributes. You can forget about coffee being bad for you, it’s actually good for you.”
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“Coffee is the number one antioxidant molecule in the American diet,” expert on polyphenols tells science writers
New York, NY – “The leading causes of death in four out of 10 cases in the United States are diet related,” said Joe A. Vinson, Ph.D. “It’s well known that an increased consumption of fruits and beverages leads to a decreased risk of chronic disease such as heart disease, stroke, diabetes and cancer.”
Dr. Vinson is Professor in the Department of Chemistry at the
The chemist said that chronic diseases cost our society over $200 billion per year in medical costs and lost productivity. He explained, “These diseases have a pathology that is initiated by free radicals. Recent epidemiology has shown that polyphenols consumed in foods may be the major agents responsible for their health benefits – not the antioxidant vitamins C and E as we’d all originally assumed. Unfortunately, measuring individual phenolic compounds is a difficult if not impossible task, due to the very large number – it’s 8000 and growing – of these compounds in plants. And that’s just one of the obstacles we encounter.
“We accepted the challenge,” Dr. Vinson said. “Our research group used market samples of common fruits, vegetables, spices, nuts, grains, oils and beverages to determine the total amount of phenols in foods and beverages using an analysis that measures the extract’s antioxidant activity. We also measured the quality of antioxidants in foods and beverages by means of an in vitro ‘heart disease in a test tube’ model.”
Dr. Vinson told the group that foods and beverages are better antioxidants than are antioxidant vitamins. He noted, “With the polyphenol content data and the USDA database of per capita food consumption, the contribution of each type of food to the average estimated intake of phenolic antioxidants was calculated for 2003. Total per capita phenolic antioxidants in the
“Coffee was the largest single contributor on a daily basis for the average American, contributing 31% of the total daily antioxidants. Coffee is high in phenolic acids and chlorogenic acid, and is the number one antioxidant molecule in the American diet,” the professor explained.
“But do high polyphenol foods and beverages act as antioxidants in the body?” he asked. “Coffee given to humans increases plasma antioxidant capacity, and the polyphenol metabolites act as antioxidants at the level of low density lipoprotein (LDL), decreasing its oxidizability, a possible benefit for slowing down the atherosclerosis process and lowering the risk of heart disease. Recent studies have shown that milk drunk in coffee does not inhibit the absorption of polyphenols in a cell and animal experiment, although recent research suggests that milk in tea interferes with biological effect and presumably antioxidant absorption. Other high polyphenol foods such as tea, chocolate and red wine have the same effects on plasma antioxidant capacity and LDL oxidation.”
Dr. Vinson said that polyphenols, including those in coffee, can also affect oxidative stress by acting both directly as antioxidants and indirectly by affecting cell signaling and gene expression. He concluded, “Polyphenols have antioxidant, anti-inflammatory, antiproliferative, anti-angiogenic, antithrombic and vasorelaxive properties, which can affect disease and its pathology.”